There will be presets for Basic Systems, such as Health, Endurance, Magic, Food etc. So right from the beginning each of the Mods can make Compat with those Systems to bridge the Gap. That is why Damage Events can for example be of the “Damage to Mana” Type without having to specify which type of Energy is being drained.
And no matter which Damage is done, all of them will specify where on the Body the hit has landed. A Vampire draining from your Neck will clearly deal more damage than them biting into your Finger.
P.S. I would think of Chi as different from Mana, as it is more based on “Life Force”. For example a Jedi/Sith would use the Chi System instead of the Mana System. Obviously Monks/Ninjas would use the same System.